Research

Evidence is the product.

Seven years of published research, registered trials, and longitudinal outcomes.

01 / Outcomes

Outcomes from active-controlled, peer-reviewed trials.

Published in the American Journal of Gastroenterology (2025): 81% of participants in a gut-directed hypnotherapy program met the IBS-SSS responder threshold at 6 weeks, compared with 63% on active control (n=244).1 Published in JMIR Formative Research (2025): 76% of participants in a clinical hypnotherapy program reported ≥50% reduction in daily hot flashes (n=139). Persistent benefit at follow-up across both cohorts. Results from peer-reviewed studies; individual outcomes vary.

ProgramEndpointEffectComparator / cohortSource
NervaIBS-SSS reduction ≥50 pts at 6wk81%vs. 63% active controlAnderson, AJG 2025
NervaAbdominal pain severity reduction71%vs. 35% active controlAnderson, AJG 2025
NervaQuality of life increase+28%AJG cohortAnderson, AJG 2025
Evia≥50% reduction in daily hot flashes76%real-world cohortScheffrahn, JMIR 2025
Hypnosis (clinical)Avg pain reduction vs. control (meta-analysis)79%19 RCTsMilling, 2021 meta-analysis
Working with researchers from:
02 / Publications

Published in top journals.

03 / Active research

Where the research is going next.

DGBI expansion

Gut-directed hypnotherapy beyond IBS. Bloating, distension, and upper GI symptoms in adults with disorders of gut-brain interaction.

FocusSymptom severity across bloating, distension, and upper GI scales

Comorbidity research

How Mindset programs perform in patients with overlapping conditions. IBS with endometriosis, interstitial cystitis, and inflammatory bowel disease.

FocusIBS-SSS, pelvic-pain composites, and IBD activity scores in overlapping populations

GI demographics

Outcomes in populations our published trials have not yet reached. Pregnancy, paediatrics, and underserved cohorts.

FocusSafety and symptom change across pregnancy, paediatric, and underserved cohorts

Health system validation

Controlled studies inside national health systems and academic referral pathways. Real-world adoption, not just efficacy.

FocusSymptom reduction inside controlled NHS arms; referral conversion through academic pathways

Biometrics

Wearable signals layered onto the Mindset model. Heart rate and sleep used to predict response and time sessions.

FocusHeart-rate and sleep signals as predictors of who responds, and when to time sessions

Predictive personalisation

Models that match the right program, intensity, and timing to each person, drawing on response data from across the cohort.

FocusMatching program type, intensity, and session timing to each person from cohort-level data
For researchers

Conduct research with us.

Research enquiriesHow the model works