Help members reduce unnecessary GI visits and avoidable ER care with an AI care program offered at no upfront risk.
Many members with IBS and functional GI symptoms sit between self-care and specialty care. They are not complex IBD cases, but they cycle through specialist visits, repeat imaging, endoscopy, medication trials, and ED visits for unexplained abdominal pain without durable symptom control. Much of this utilization is clinically avoidable. The underlying pathology is functional, not structural, and responds to brain-gut behavioral therapy.
Annual US GI healthcare spending.
Most common reason for ED visits among US adults.
of GI volume is functional.
Sources: PHTI Virtual Gastrointestinal Care Solutions, March 2026; Peery et al., Gastroenterology 2025; Wu et al., Academic Emergency Medicine 2025.
For many members with IBS and functional GI symptoms, the clinical issue is not structural disease. It is dysregulation across the gut-brain axis: pain sensitivity, motility, threat response, and symptom amplification. Nerva delivers an AI brain-gut behavioral program via a member’s phone over six weeks, targeting that loop directly.
Nerva gives members with IBS and functional GI symptoms a personalized care program that targets the brain-gut loop behind functional symptoms, without requiring specialist visits to start.
Built for IBS, functional dyspepsia, and DGBI symptoms where structural disease is not the main driver.
Guided behavioral sessions help members regulate gut sensitivity, symptom anxiety, and stress-driven flare-ups.
The program adapts to each member's symptoms, goals, and progress through assessment, tracking, and AI-guided support.
Phone-based delivery is what lets Nerva serve the entire functional GI cohort, not a pilot slice. Built for full books of business, not curated cases.
Reported at least a 30% reduction in abdominal pain severity at 6 weeks, vs 35% on active control.
Met the IBS-SSS responder threshold at program completion, vs 63% on active control.
Modeled gross-to-cost ratio for an outcome-aligned Nerva contract.
Anderson, Peters, Gibson, Halmos. AJG 2025;120(2):440-448 (RCT, n=244). ROI modeled from PHTI 2026 wraparound virtual GI category benchmarks and Mindset Health program cost.
Nerva complements specialty GI vendors and in-network GI practices. It is built for the functional GI middle they are often too expensive to serve at scale.
Enrollment is the hardest part of any payer pilot. We’ve already built the engine for it: a member experience refined over years of US delivery, and a nationwide provider network actively referring patients to us.
Real-world Nerva delivery in the US, built up over years. Not a pilot, not a paid placement. The outcomes data on this page comes from this cohort.
Gastroenterologists, advanced practice providers, and dietitians have referred patients to Nerva. Clinical adoption from the bottom up, validated by the people who treat IBS every day. No other functional GI vendor has built this referral footprint.
Selected for CMS ACCESS in MSK and behavioral health. The same Medicare-aligned discipline (eligibility, outcomes, reporting, risk-bearing payment) now applies to commercial GI through Nerva.
Members run the program from their phone, no clinician intake. That is what makes functional GI care viable at population scale, on software economics.
Peer-reviewed AJG 2025 trial against an active control. Validated symptom tracking. Outcomes you can contract against pre-agreed thresholds.
Symptom tracking and outcome reporting contracted against pre-agreed thresholds. Symmetric risk: withhold on our side, not just yours.
“Within the evidence reviewed, Nerva presented the strongest overall evidence for improving IBS symptoms.”
PHTI also modeled meaningful savings for wraparound virtual GI solutions for IBS. Treat these figures as category benchmarks, not a Nerva-specific guarantee.
Read the PHTI assessmentCMS ACCESS is a new 10-year Original Medicare model paying for outcomes, not activity. Mindset Health was selected for the MSK and behavioral health tracks. We apply the same operating discipline to commercial GI through Nerva, across commercial, Medicare Advantage, and ASO books.
Drag your covered lives below to see what an outcome-aligned contract could return in year one.
Illustrative estimate based on fixed GI eligibility, expected year-1 enrollment, $2,600 gross annual savings per enrolled member, and $500 annual program cost. Directional estimate only; actual savings depend on population, claims mix, engagement, and contract terms.
Talk to our teamSelected applicants list, CMS ACCESS model. ACCESS launches July 5, 2026.
“My gut and my brain were stuck in a panic loop. A few weeks into Nerva, that signal shifted. I’m eating normally again, cooking with my family, going out without the dread.”
Your members are already moving through GI consults, repeat diagnostics, ED visits, and untreated symptoms. Mindset gives them a scalable, AI-powered care path built for IBS and functional GI, with evidence-backed brain-gut behavioral therapy and commercial terms tied to outcomes.
